Timolol Maleate 0.5% Eye Drop Preparation

Timolol Maleate 0.5% Eye Drop Preparation Formulation of eye drops (TIMOLOL MALEATE 0.5% m/V EYE DROPS) By: Introduction The Timolol Maleate 0.5% M/V Eye Drops is indicated for the reduction the intraocular pressure in the (IOP) persons suffering from ocular hypertension or glaucoma they are insufficiently responsive to the topical Beta Blockers. It is shown to reduce IOP in patients that have chronic open-angle glaucoma, ocular hypertension, and in Aphakic patients with signs of glaucoma and in those patients who wear contact classes (Siegal, 2007). It also shows a reduction of IOP in patients having narrow angles and those with iatrogenically-induced narrow angle closures. The inactive ingredients or excipients in Timolol sodium hydroxide used for pH adjustment, monobasic and dibasic sodium phosphates, and purified water. Purified water is used for injection purposes. 0.01% Benzalkonium chloride is used as a preservative. The preservative is a quaternary ammonium. Its mechanism of action involves the intrinsic detergent processes that result in the dissolution of the bacterial membranes and cell walls, thus preserving the medicine (Wang et al., 2012). It is particularly focused on the preservation against gram-positive bacteria. The aim of this project is to prepare a Timolol maleate 0.5% eye drop using the sterilization method. The autoclave sterilization method is based on the WHO standard. Methods Alcohol wipes were used to initially clean the top panel of the laminar flow cabinet. The direction of cleaning was from back to front (from one corner towards the airflow direction). It was wiped twice while ensuring that the wiping stripes overlapped. It was disinfected until the top panel. Then, starting from one side of the panels, it was disinfected until the bottom of the panel. The processes were repeated until all the side panels and bottom panels were adequately disinfected. The production sheet record was filled and completed before the start of the experiment. 50 ml of Timolol maleate was weighed; Disodium Hydrogen Orthophosphate and Dihydrogen Sodium Phosphate were also weighed and put in separate test tubes. Centrimide 0.5% Stock Solution was added to half of distilled water in a beaker. The mixture was stirred gently. Disodium Hydrogen Orthophosphate and Dihydrogen Sodium Phosphate were added to the mixture and stirred to dissolve. Timolol maleate was added to the mixture and stirred to dissolve. Freshly distilled water was added to the solution to make up to the final volume. Sintered glass filter method was used. The filtrate was put into the beaker. It was then poured into pre-sterilized bottles. The filtrate was filled up to the bottle shoulder. The dropper was inserted into the bottles, and caps screwed tightly by hand (WHO, 2002). Autoclave sterilization was carried out on the solution at 121-124 oC. The process was carried out for 15 minutes at approximately 200 kPa or 1 atmosphere above the atmospheric pressure. The solution was viewed and labelled after sterilization and cooling of the solution. Results Table 1: Microbiological methods Table: 2. Environmental monitoring Settle Plates should be accurately positioned in the Laminar Flow Cabinet by placing one settle plate for each corner. That is, one should be placed to the back left, one to the back right, one to the front left and one to the front right. A minimum of 10 cm gap should be left between the settle plates and the walls of the cabinet. Figure: 1. Autoclave controls before sterilization Figure: 2. Results after sterilization Discussion As shown in figure 2, the autoclave turned black after the sterilization process. This shows that it was sterilized. The Sterikon ® Plus indicators have nutrient broth made up of sugar, spores of a pathogenic bacillus stearothermophilus and a pH indicator. When the sterilization process is carried out, the ampules in the indicator retain the red-violet color. On the other hand, if sterilization does not take place, then bacterial growth occurs. This leads to ampules becoming turbid and changing color to yellow (Block, 2001). The manufacturing processes are valid and the cleanliness levels achieved throughout the sterilization process. From table 1, there was growth in aerobic tests in a nutrient broth medium and fungal tests in a Yeast dextrose broth medium. This indicates that the conditions were favorable for growth. The anaerobic control and fungal control also indicated growth under Robertson’s cooked meat medium and Yeast dextrose broth media respectively. From table 2, there was no growth all the settle plates placed in different positions. The sterilization process is a reliable approach because high temperatures are achieved through steam under pressure mechanisms. The moist heat reaches temperatures above the boiling point, thus achieving effective sterilization. This approach is the best because pressurized steam destroys all forms of life and bacterial spores (Mazhar, 2009). References Block, SS 2001, Disinfection, Sterilization, and Preservation. London: Lippincott Williams Wilkins. Mazhar, H 2009, Autoclaving: Real Sterilization. Viewed 23 January, 2014 fromhttp://microbiologyon-line.blogspot.com/2009/08/autoclaving-real-sterilization.html Siegal, PA 2007. Glaucoma Medical Therapy: Principles and Management: Principles and Management. Oxford: Oxford University Press. Wang, H, Switlick, K, Ortiz, C, Zurita, B Connor, C 2012. Health Insurance Handbook: How to Make It Work. World Bank Publications. WHO 2002, The Local Small-Scale Preparation of Eye Drops: Eye Drop Update 2002.WHO/PBL/01.83 Standard Operating Procedure A Cleaning and Disinfecting Laminar Flow Cabinets Step 1: Wear suitable Size Gloves. Step 2: Using alcohol wipes initially wipe the top panel of the laminar flow cabinet starting from one corner and in the direction of the airflow (i.e. from back to front). Repeat this process for another strike. But ensure that the wiping strips overlap. Continue disinfecting until reaching the other side of the top panel. Every now and then turn around the alcohol wipe to use a clean side. Step 3: Starting from one of the side panels, place an unused alcohol wipe on the top and the back corner of the panel, and wipe in the direction of the airflow (i.e. from back to front.) Repeat this process for another strike, but ensure that wiping strips overlap. Continue disinfecting until reaching the bottom panel. Every now and then turn over the alcohol wipe to use a clean side. Step 4: Apply the step 2 process for the other side panel. Step 5: Apply step 1 process for the bottom panel. Standard Operating Procedure B Positioning Settle Plates inside a Laminar Flow Cabinet Step 1: Place one settle plate in each corner, i.e. one to the back left, one to the back right, one to the front left and one to the front right. Step 2: Give a minimum of 10 cm gap between the settle plates and walls of the cabinet. QC SHEET Manufacturers Label Name: Timolol Maleate 0.5% Eye Drops (TIMOPTIC-XE) Type of Medicine: Beta-blocker eye drop preparation Use: Chronic open angle glaucoma Available as: Eye drops, eye gel, single-use eye drops Manufacturer Code: TM5483-67 Manufacture License: TM3421-564-6 Expiry Date: 12:01:2015 Manufacturer Address: MJU Advertising LLC PO BOX: 22874 OUT METHA, DUBAI UNITED ARAB EMIRATES Raw Material Identification and Quantification Active: Brimonidine Tartrate 0.2% w/v Timolol Maleate IP equivalent to Timolol 0.5% w/v Inactive Ingredients: Sodium chloride, Disodium EDTA, Sodium dihydrogen Phosphate dihydrate, Disodium hydrogen phosphate, Sodium hydroxide, Water for Injections.

The Stupidest Angel Chapter 20

Chapter 20 WINGING IT The angel had opened six envelopes of powdered hot-chocolate mix and handpicked out all the minimarshmallows. â€Å"They trap them in these little prisons with the brown powder. You must free them to put them in the cup,† the angel explained, tearing open another packet, pouring the contents into a bowl, picking up the little marshmallows, and dropping them into his mug. â€Å"Kill him while he's counting the marshmallows,† said the Narrator. â€Å"He's a mutant. No angel could be that stupid. Kill him, you crazy bitch, he's the enemy.† â€Å"Nuh-uh,† said Raziel, into his marshmallow foam. Molly looked at him over the rim of her mug. By the candlelight in the kitchen, he certainly was a striking fellow – those sharp features, the lineless face, the hair, and now the chocolate-marshmallow mustache. Not to mention the intermittent glowing in the dark, which had been helpful when she was looking for some matches to light the candles. â€Å"You can hear the voice in my head?† she asked. â€Å"Yes. And in my head.† â€Å"I'm not religious,† Molly said. Under the table, she held the tashi with her free hand, its blade resting across her bare thighs. â€Å"Oh, me either,† said the angel. â€Å"I mean, I'm not religious, so why are you here?† â€Å"Lunatics. We're attracted to them. It has something to do with the mechanics of faith. I don't really understand it. Do you have any more?† He held up the empty cocoa envelope. His mug was overflowing with melted marshmallow foam. â€Å"No, that's the whole box. So you're attracted to me because I'm loony and will believe anything?† â€Å"Yes, I think so. And because no one will believe you. So there's no violation of faith.† â€Å"Right.† â€Å"But you are attractive in other ways, too,† added the angel quickly, as if someone had suddenly smacked him in the head with a sock full of people skills. â€Å"I like your sword and those.† â€Å"My breasts?† It wasn't the first time that someone had said that sort of thing to her, but it was the first time it had come from a messenger of God. â€Å"Yes. Zoe has those. She's an archangel like me. Well, not like me. She has those.† â€Å"Uh-huh. So there are female angels as well?† â€Å"Oh yes. Not always. Everyone was changed after you happened.† â€Å"Me?† â€Å"Man. Mankind. Women. You. Before we were all one kind. But then you happened, and we were divided up and given parts. Some got those, others got other things. I don't know why.† â€Å"So you have parts?† â€Å"Would you like to see?† â€Å"Wings?† Molly asked. She actually wouldn't mind seeing his wings, if he had them. â€Å"No, we all have those. I mean my special parts. Would you like to see?† He stood and reached down the front of his pants. It wasn't the first time she'd had an offer like that, but it was the first time it had come from a messenger of God. â€Å"No, that's okay.† She grabbed his forearm and guided him back into his seat. â€Å"Okay, then. I should go. I have to check on the miracle and then go home.† â€Å"The miracle?† â€Å"A Christmas miracle That's why I'm here. Oh look, you have a scar on one of them » â€Å"He has the attention span of a hummingbird,† the Narrator hissed â€Å"Put him out of his misery â€Å" The angel was pointing to the jagged five-inch scar above Molly's left breast, the one she'd gotten when a stunt went wrong while filming Mechanized Death Warrior Babe VII. The injury that had gotten her fired, the scar that had ended her career as a B-movie action heroine. â€Å"Does it hurt?† asked the angel â€Å"Not anymore,† Molly said â€Å"Can I touch?† It wasn't the first time that someone had asked, but – well, you know. â€Å"Okay,† she said. His fingers were long and fine, his fingernails a little too long for a guy, she thought, but his touch was warm and radiated from her breast through her whole body When he pulled his hand away, he said, â€Å"Better?† She touched where he had touched It was smooth. Completely smooth. The scar was gone. The angel blurred in her vision as tears welled up in her eyes. â€Å"You complete shit bag of sentimental saccharine,† said the Narrator â€Å"Thank you,† Molly said, with a hint of a sniffle â€Å"I didn't know you could –  » â€Å"I'm good with weather,† said the angel. â€Å"Idiot!† the Narrator said â€Å"I have to go now,† said Raziel, rising from his chair â€Å"I have to go to the church to see if the miracle has worked » Molly led him through the living room to the front door. She held the door for him. Even so, the wind whipped his coat around him and she could see the white tips of his wings below. She smiled, laughing and crying at the same time. â€Å"Bye,† the angel said. He walked away into the woods. As Molly closed the door, something dark flew through it. The candles in the living room had blown out, so all she could see was a shadow flying through the house, disappearing into the kitchen. She got the door shut and trod into the kitchen, holding her sword at a low ready. By the candlelight in the kitchen, she could see the shadow over the kitchen window, two eyes shining orange back there in the dark. She picked up a candle from the table and moved toward the window until the shadow cast shadows of its own. It was some kind of animal, hanging from the shutter over the sink, looking like a black towel with a little doggy face. It didn't seem dangerous, just, well, a little goofy. â€Å"Well, this is it I am getting back on my meds tomorrow, if I have to borrow the money from Lena » â€Å"Not so fast,† said the Narrator. â€Å"It'll be so lonely in here when I'm gone. And you'll be back to wearing your normal clothes. Jeans and sweaters, you can't want that.† Ignoring the Narrator, Molly approached the creature on the shutters until she was only two feet away and staring right into its eyes. â€Å"Angels are one thing, but I don't even know what in the hell you are, little guy.† â€Å"Fruit bat,† said Roberto. â€Å"He might be a Spaniard,† said the Narrator. â€Å"Did you hear the accent?† â€Å"I'm going out there,† Theo Crowe said, finding a grip on the Christmas tree. â€Å"He still has one bullet,† said Tucker Case. â€Å"They are going to torch the place. I've got to get out there.† â€Å"To do what? You going to take their matches away?† Lena took Theo by the arm. â€Å"Theo, they'll never get a fire started in this rain and wind. Don't go out there. Ben didn't make it two steps.† â€Å"If I can get to an SUV, I can start running over people,† Theo said. â€Å"Val gave me the keys to her Range Rover.† â€Å"Well, that's not going to work,† said Tuck. â€Å"There's a bunch of them. You might get some of the feeble ones, but the rest will just run into the woods where you can't get to them.† â€Å"Fine. Suggestions? This place will burn like tinder, rain or no rain. If I don't do something we're going to get roasted.† Lena looked at Tuck. â€Å"Maybe Theo's right. If he can drive them into the woods, maybe the rest of us can make a break for the parking lot. They can't get all of us.† â€Å"Fine,† Theo said. â€Å"Divide people up into groups of five and six. Give the strongest member of each group the key to an SUV. Make sure everyone knows where they're going once they get out the door. When you hear the horn on the Range Rover play ‘Shave and a Haircut, it will mean I've done what I can do. Everyone make a break for it.† â€Å"Wow, you came up with that while stoned,† Tuck said. â€Å"I'm impressed.† â€Å"Just get everyone ready. I'm not going out on that roof until I'm sure no one is waiting for me.† â€Å"What if we hear a gunshot? What if they get you before you get to the car?† Theo pulled a key out of his pocket and handed it to Tuck. â€Å"Then it would be your turn, wouldn't it? Val had her spare car key with her, too.† â€Å"Wait a minute. I'm not running out there. You have an excuse, you're stoned, you're a cop, your wife threw you out, and your life is in shreds. Things are going good for me.† â€Å"When Constable Crowe leaves, then can we cut off his head?† asked Joshua Barker. â€Å"Okay, maybe not,† said Tuck. â€Å"I'm going,† Theo said. â€Å"Get everyone ready at the door.† The lanky constable made his way up the Christmas tree. Tuck watched him climb out on the roof, then turned to the others. â€Å"Okay, you guys heard him. Let's break into groups of five and six by the front doors. Nacho, grab the hammer, we're going to have to pull the nails on the reinforcements. Who's driving an SUV?† Everyone but the children raised their hands. â€Å"It won't spark, it's wet,† said Marty in the Morning. He was trying to coax fire out of a drenched disposable lighter. The undead stood around him, looking at the pile of gasoline-sodden debris they'd piled against the side of the chapel. â€Å"I love barbecue,† said Arthur Tannbeau. â€Å"Every Sunday out at the ranch, we used to –  » â€Å"Only in California could one refer to a citrus farm as a ranch,† interrupted Malcolm Cowley. â€Å"As if you and the yahoos would all go out on horseback to round up the tangerines.† â€Å"Didn't anyone find a dry lighter or matches in any of the cars?† Dale Pearson said. â€Å"No one smokes anymore,† said Bess Leander. â€Å"Disgusting filthy habit anyway.† â€Å"Said the woman who still has brain matter on her chin from that fellow in the sweater,† said Malcolm. Bess smiled coyly, most of her gums visible through her receded lips. â€Å"They were so tasty – it was like he'd never used them.† There was a chirp from the front of the chapel and all of them looked. Yellow lights flashed on one of the vehicles up there. â€Å"Someone's making a break for it,† screamed Dale. â€Å"I thought I told you to keep an eye on the roof.† â€Å"I did,† said the one-armed Jimmy Antalvo. â€Å"It's dark. I can't see shit.† As they rushed down the side of the chapel toward the front, they saw a dark shadow slide off the side of the roof to the ground.

The Indisputable Truth About Christmas Essay Topics That Nobody Is Telling You

The Indisputable Truth About Christmas Essay Topics That Nobody Is Telling You Christmas Essay Topics: the Ultimate Convenience! Eventually, it results in a large boost in your grades. Students lead busy lives and frequently forget about an approaching deadline. A lot of students put on a uniform. Christmas Essay Topics: the Ultimate Convenience! Men and women start getting ready for the Christmas well beforehand. They visit each other and make merry. They are filled with happiness. As you all know, Christmas Day is believed to be the largest celebration of Christianity and within this festival all the individuals of the Christian community are extremely enthusiastic. You may now write Christmas Essay in Hindi with the assistance of this informative article. Below you'll find top 10 ideas that you are able to use working on your Christmas essay. In England it turned out to be a different story. Writing and reading free Christmas Essay is among the most critical techniques to devote the holiday especially for kids. There are lots of Christmas traditions. Most families start with heading to church where performances and songs are finished. It is among the widely celebrated international festivals. See most people have family all around the place so as soon as the holiday comes around all of them meet up and all of them get full of joy for being in a position to finally see them again. In all families there are plenty of conventional meals on Christmas Eve. Also, individuals get to give gifts to their buddies and family members. The best thing of giving gifts is watching the people today open the gifts that were given to them. Every Christmas each family member has the capability to open a single gift. Spending Christmas with my family is vital to me. Family foods are also an additional way to get a lot of joy on Christmas day. Bake Christmas cookies with a relative or friend. Whenever you choose to ask us for skilled support, don't hesitate to get in touch with our support managers. 1 thing that lots of families may come across interesting is sharing stories. If children are given choice about what they're writing about, they'll be a whole lot more excited about writing. This story is all about visiting the beach. Throughout the planet, people from various ethnic groups each have a method of showing their Christmas character. Begin with a capturing and intriguing hook. There ought to be up to three supporting points in every single body paragraphs. Utilize your own personal experience to explain your perspective. Just click the image below and it'll take you to the resource. How to compose argumentative essay smoking it's not sufficient to truly feel passionate about a particular point of view to compose a productive argument essay, you must be. There are several possible compare and contrast essay topics, and a number of them are tough to perform. So many details inside her picture! If you've read about how to compose a fantastic essay, you are aware that it should begin with a hook sentence. Thus, for your coursework, you're want to have the very best ideas. This post is for you also. Well, grading papers can be rather dull. Gossip, Lies and Christmas Essay Topics A number of the family might not have been seen in a very long time so that it puts everyone in a great mood to finally see them. My wife is all about to get a kid. All in all a person ought to be careful of argumentative men and women, include all neighbors, not to mention the whole family. Using pathetic fallacy makes a dull atmosphere which matches the atmosphere made by Scrooge. Christians are spread all around the world with varying numbers from nation to nation. It's clear the authentic happiness comes from good deeds and money doesn't bring an abundance of happiness. Folks should do some research on who's quarreling and who's at peace with the majority of the people that an individual could be inviting.

I Choose For This Report Is Call Infidel An Autobiography...

The book I choose for this report is call Infidel an autobiography of Ayann Hirsi Ali. My literature professor recommend this book to me about a year ago and I never got around to reading it. Then when we were assigned this report I know that it was a good book for this paper. I’m excited that I finally got to around to reading it. Ayaan Hirsi Ali was born in Mogadishu, Somalia where she spent her early childhood years living with her mother, brother, sister, and grandmother. Her father at that time was in prison. Although he does escape prison and ends living in Ethiopia for a while before morning to Saudi Arabia. When he moves there his family eventually moves there to join him. Ayaan Hirsi Ali was raised in a strict Muslim family. She has endured civil war, female mutilation, brutal beatings, and a life of moving from one troubled country to another that were unstable and ruled by dictators. Application of Ecological System Theory Microsystem Protective factors. Her sister was a protective factor. Ayaan’s sister would try to help learn what was appropriate and what wasn’t in their culture. By doing this her sister was trying to help her stay out of trouble or in this case to keep the number of times she was beaten to a minimum. Later on in her life she went to Germany to visit relatives while waiting for her papers to go to Canada she decides to run away after remembering the story a friend told her about how her and her husband ran traveled together and become